Luis Maesso was born in Madrid. He graduated as an actor from RESAD (Royal School of Dramatic Art), and trained with teachers such as Fernando Piernas, José Masegosa, Miguel del Arco, and Lidia Otón, among others. He has worked on TV series such as La Promesa, Maricón Perdido, and La Templanza, in theatre plays such as The Rhythm of the Night, and in musicals such Rent as Tina and Romeo and Juliet. He has also performed on numerous occasions at the Teatro de la Zarzuela, and has done performance art, short films, and voice-over work. He also teaches at El Estudio de Actores and has his own contemporary theater company, InDubio.