Edu Rejón was born in Spain and raised in Seville, in the south of the country. Before pursuing acting, he studied Law in Barcelona, Freiburg (Germany), and Bologna (Italy). He is fluent in Spanish, Italian, English, German, and has a basic knowledge of Russian.

Edu began his acting career in theater in Madrid. His first professional film role was in Morir (2018), directed by Fernando Franco. Over the years, he continued to build his career, working on a variety of projects in both film and television. Notable roles include working with acclaimed directors such as Daniele Luchetti in My Brother is an Only Child and starring in Tolo Tolo alongside Checco Zalone.

More recently, he starred in Saturn Return (directed by Isaki Lacuesta and Pol Rodríguez), a film selected by the Spanish Academy of Cinematic Arts to represent Spain at the Oscars. He works across Spain and Italy, where he was part of the cast in the third season of My Brilliant Friend.

In addition to his screen work, Edu is deeply involved in theater, performing in both classic and comedic productions throughout Spain. He is also an advocate for independent theater and short films, frequently collaborating with emerging directors and new voices in the industry.