Gianluca Zaccaria graduated from the Centro Sperimentale di Cinematografia and has worked with leading directors of Italian cinema, including Fabio Grassadonia and Antonio Piazza (Iddu), Gianni Amelio (Campo di battaglia), Marco Bellocchio (Esterno notte), and Nanni Moretti (Tre piani).

On television, he has played principal roles in several series, including Mike, directed by Giuseppe Bonito; Mameli, directed by Luca Lucini and Ago Panini; Il nostro Generale, directed by Lucio Pellegrini; and Il Patriarca, directed by Claudio Amendola.

In theatre, he has worked under the direction of Vito Mancusi in Beirut Rocks by Israel Horovitz and with Eljana Popova in Chekhov’s The Three Sisters. He is currently co-directing and performing in Come un amuleto, a contemporary play by Fulvia Cipollari.

In 2024, he received the  "Occhio al Talento" award from RB Casting Magazine.